The desquamation process starts with the degradation of corneodesmosomes (modified desmosomes present in the SC) and is controlled by a number of proteases and their inhibitors. The constant thickness of the epidermis is maintained by the fine balance between basal cell proliferation and corneocyte desquamation. Also, it contributes to the hydration of the SC by proteolysing into pyrrolidine carboxylic acid and transurocanic acid in conditions of low water content. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.įilaggrin is a particularly important molecule in the SC, as it facilitates the aggregation of keratin filaments of the cytoskeleton into bundles, consequently collapsing corneocytes into flattened disks. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review.
In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Background: Vitamin D is a secosteroid, which was initially known for its skeletal role however, in recent years, its functions in different organs have been increasingly recognized.
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